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. 2021 Mar 30;65(1):41–53. doi: 10.1165/rcmb.2021-0005OC

Figure 1.

Figure 1.

Tripartite interaction between spike protein (S protein) (green), recombinant fragment of human SP-D (surfactant protein D) (rfhSP-D) (red), and ACE-2 (angiotensin-converting enzyme 2) (blue) (A and B). ACE-2 residues Ser19, Lys31, Glu35 and His34 interact with both S protein and rfhSP-D. The interactions between S protein and ACE-2 are deduced from the crystal structure (Protein Data Bank identification 6VW1), and those between rfhSP-D and ACE-2 protein are based on docked complexes. B is a zoomed view of A. Individual intermolecular interactions between (C) S protein (green) and ACE-2 (blue), (D) S protein (green) and rfhSP-D (red), and (E) rfhSP-D (red) and ACE-2 (blue). The S protein residues Tyr449, Gln493, and Gln498 participate in intermolecular interactions with both ACE-2 and rfhSP-D.