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Changes of CSF routine parameters during 14 months of nusinersen treatment
| CSF routine parameter | n | Baseline median (IQR) | 14-month analysis median (IQR) | p value |
|---|---|---|---|---|
| CellCount (MPt/L) | 57 | 1.0 (0.0–2.0) | 1.0 (0.15–1.0) | n.s |
| Qalb (× 10–3) | 56 | 4.1 (3.3–6.1) | 4.7 (3.7–6.3) | 0.000359*** |
| Protein (mg/L) | 58 | 308 (244–419) | 345 (283–443) | 0.000246*** |
CSF cerebrospinal fluid, Qalb ratio of serum/CSF albumin, IQR interquartile range, n.s. not significant
***p < 0.001 calculated by Wilcoxon signed-rank test
