Table 4.

Rapid desensitization protocol via subcutaneous insulin Glargine. Adapted from Hasani-Ranjbar et al.

[24]

Day	Dose	Time between doses	Recommendations
1	Administer 0.0001U, 0.001U, 0.01U, 0.1U, 1U	30-min intervals	Check blood glucose levels and vitals q30 min
2	Administer 2U, 4U, 8U and 20U	30-min intervals	In case of a local reaction, treat with an antihistamine and the last dose is repeated until no reaction occurs and then the dose increases are continued
			If there are systemic reactions, treat with epinephrine and an antihistamine. Reduce the dose to one half
			At high insulin doses, a 10% glucose solution can be given to counteract the glucose-lowering effect