Table 1.
Comparison among patients with mild, moderate or severe COVID-19.
| Mild (not hospitalised)(n=11) | Moderate (no ICU, death)(n=25) | Severe (ICU, death)(n=24) | P | |
|---|---|---|---|---|
| Age (years) | 46.3 (34.2; 51.3) | 59.5 (52.1; 67.5)* | 62.7 (57.7; 70.3)* | 0.001 |
| Male gender | 4 (36.4) | 18 (72.0) | 19 (79.2)* | 0.043 |
| Obesity | 2 (18.2) | 8 (32.0) | 9 (37.5) | 0.499 |
| Hypertension | 2 (18.2) | 8 (32.0) | 11 (45.8) | 0.259 |
| CAD | 0 (0.0) | 1 (4.0) | 5 (20.8) | 0.049 |
| Diabetes | 1 (9.1) | 5 (20.0) | 6 (25.0) | 0.551 |
| CKD | 0 (0.0) | 0 (0.0) | 2 (8.3) | 0.152 |
| PaO2/FiO2 | 368.6 (333.8; 401.4) | 276.2 (221.4; 324.1)* | 151.6 (58.0; 271.8)*,# | 0.001 |
| NLR | 3.2 (2.2; 6.1) | 5.9 (3.9; 8.0) | 7.7 (5.4; 16.1)* | 0.002 |
| CRP (mg/dL) | 19.8 (8.2; 73.4) | 96.2 (38.0; 156.5)* | 126.2 (66.3; 267.6)* | 0.001 |
| Glucose (mg/dL) | 94.5 (86.8; 105.5) | 110.0 (101.5; 119.0) | 133.0 (107.8; 162.0)* | 0.001 |
| LDH (U/L) | 253.5 (197.2; 333.8) | 371.0 (307.8; 487.3)* | 539.0 (369.0; 725.0)* | 0.001 |
| Leptin (ng/mL) | 6.7 (3.8; 7.9) | 5.2 (1.3; 10.2) | 5.6 (2.9; 13.3) | 0.664 |
| Adiponectin (µg/mL) | 4.1 (2.7; 14.7) | 24.3 (3.4; 39.2) | 20.8 (3.5; 29.7) | 0.112 |
| Adpn/Lep | 1.2 (0.5; 2.0) | 5.0 (1.6; 11.2)* | 2.1 (1.0; 3.6) | 0.019 |
⁎
P 0.05 vs. mild;
#
P 0.05 vs. moderate. Categorical variables are expressed as counts (percentage). Abbreviations: CAD, coronary artery disease; CKD, chronic kidney disease; PaO2/FiO2, arterial partial pressure of oxygen measured on arterial blood gas analysis divided by the fraction of inspired oxygen (unitless); NLR, neutrophil to lymphocyte ratio (unitless), CRP, high-sensitivity C-reactive protein; LDH, lactate dehydrogenase; Adpn/Lep, adiponectin to leptin ratio (unitless).