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. 2021 Jul 28;9(7):e002528. doi: 10.1136/jitc-2021-002528

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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MYC is associated with non-inflamed microenvironment in TNBC. (A) Heatmap indicating the quantified cytolytic activity of the local immune infiltrate between inflamed and non-inflamed TNBC tumors. (B) Pathological scores of sTILs and iTILs in inflamed and non-inflamed tumors. (C) IHC scores for CD8⁺ T cells in inflamed and non-infalmed tumors. (D) The CNV landscape of non-inflamed and inflamed tumors revealed that the largest difference between non-inflamed and inflamed tumors located in 8q24.13-8q24.3 segment (MYC). (E) The fractions of various types of CNVs of MYC in non-inflamed and inflamed tumors. (F) The comparison of copy number value (log2 copy number/ploidy) of MYC between the non-inflamed and inflamed tumors. (G) Upregulated GO terms related to MYC pathways in non-inflamed tumors compared with inflamed tumors. The data are presented as the median with IQR (B, C); two-tailed unpaired Student’s t test (B, C, F), chi-square test (E). ***P<0.001. CNV, copy number variation; GO, gene ontology; IHC, immunohistochemistry; IQR, interquartile range; NES, normalized enrichment score; sTIL/iTILs, stromal and intratumoral tumor-infiltrating lymphocytes; TNBC, triple-negative breast cancer.