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Combined numbers needed to treat values for drug classes recommended for painful DN. The circle sizes indicate the relative number of patients, who received active treatment drugs in studies for which dichotomous data were available. Gabapentin ER = gabapentin extended release or enacarbil; NNT = needed to treat; SNRIs = serotonin noradrenaline reuptake inhibitors; TCAs = tricyclic antidepressants. Updated from Finnerup et al.110,111
