Table 4.
Association Between any Immunosuppressive Therapy and BSIs in the Propensity Score Matched Population
| Testing of association between any immunosuppressive therapy and BSIs in entire propensity score matched population (n = 6520) | ||||
|---|---|---|---|---|
| Parameter | Univariable OR (95% CI) | P value | Multivariablea OR (95% CI) | P Value |
| Immunosuppressive therapy (yes vs no) | 1.25 (0.97, 1.62) | .0885 | 1.10 (0.83, 1.46) | .5059 |
| Testing of association between immunosuppressive category and BSIs in entire propensity score matched population (n = 6510) b | ||||
| Immunosuppressive category | Univariable OR (95% CI) | P Value | Multivariablea OR (95% CI) | P Value |
| Steroid alone vs none | 0.87 (0.60, 1.26) | .4541 | 0.78 (0.53, 1.15) | .2019 |
| Anakinra alone vs none | 1.00 (0.06, 15.99) | 1.0000 | 0.82 (0.05, 13.31) | .8877 |
| Tocilizumab alone vs none | 1.80 (0.60, 5.37) | .2920 | 1.98 (0.64, 6.10) | .2361 |
| Steroid + Anakinra vs none | 2.00 (1.05, 3.80) | .0342 | 1.54 (0.79, 3.02) | .2092 |
| Steroid + Tocilizumab vs none | 2.13 (1.16, 3.94) | .0155 | 1.97 (1.04, 3.73) | .0386 |
| Steroid + Anakinra + Tocilizumab vs none | 1.00 (0.32, 3.10) | 1.0000 | 0.81 (0.24, 2.70) | .7251 |
Bolded P values indicate those P values that are clinically significant (P value < .05).
Abbreviations: CI: confidence intervals; OR: odds ratio.
aAfter backwards selection was applied, final multivariable model was adjusted for age, ICU, CRRT, inotrope/ vasopressor use, and presence of CVC.
bThe number of study patients who received Anakinra + Tocilizumab were too small (n = 10) to perform meaningful statistical analyses and so they were excluded.