Table 1.
List of gene sets positively and negatively enriched in CNS-invading CD4 T cells
| Gene set | Normalized enrichment score | P-value |
|---|---|---|
| TNFα signalling via NF-κB | 2.188 | <0.001 |
| KRAS signalling | 1.876 | <0.001 |
| NOTCH1 intracellular domain regulates transcription | 1.871 | 0.001 |
| Nuclear receptor transcription pathway | 1.844 | 0.001 |
| Cytokine-cytokine receptor interaction | 1.811 | <0.001 |
| TNF receptor superfamily TNFSF members mediating non-canonical NF-κB pathway | 1.800 | 0.003 |
| IL-2/STAT-5 signalling | 1.770 | <0.001 |
| Type I diabetes mellitus | 1.744 | 0.001 |
| Inflammatory response | 1.744 | <0.001 |
| TGFβ signalling | 1.692 | 0.004 |
| Hypoxia | 1.639 | <0.001 |
| p53 pathway | 1.602 | 0.001 |
| IL-6/JAK/STAT-3 signalling | 1.548 | 0.012 |
| E2F targets | −1.583 | <0.001 |
| Minichromosome maintenance pathway | −2.051 | <0.001 |