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. 2021 Jun 9;8(7):ofab267. doi: 10.1093/ofid/ofab267

Table 3.

Prevalence of Genotype 6 RAS in Cohort (RAS Definitions From EASL Guidelines 2020 [46])

Subtype n Daclatasvir RAS Detected (n) Sofosbuvir RAS Detected (n)
6a 21 F/L28V (3); L31M (1) L159Fb (1)
6e 14 F/L28V (7); L28M (5); R30S (14)a; L31I (1); T93S (1) None detected
6h 1 F/L28Va (1) None detected
6k 1 F/L28Va (1) None detected
6l 2 F/L28Va (2) None detected
6o 2 F/L28V (1); T58A (1) T93S (1) None detected

Abbreviations: EASL, European Association for the Study of the Liver; RAS, resistance-associated substitutions.

aRAS is considered wild type for this genotype.

bNot considered clinically relevant RAS for genotype 6 but has been shown to be treatment emergent.