Figure 1.

Age-dependent whole-brain distribution of α-syn pathology in old (18 months), late adult (10–12 months) and young (3 months) rats seeded with α-syn aggregates in the gut. The Paxinos rat brain atlas is used for anatomical reference, bregma coordinates are in millimetres. The colour scale represents the optic density value of phosphorylated α-syn pathology in a certain brain area. Amg = Amygdala; C-A = cortical-amygdala transition area; CingC = cingulate cortex; Cp = cerebral peduncle; CPu = caudate putamen; EntC = entorhinal cortex; GP = globus pallidus; HC = hippocampus; Hypoth = hypothalamus; IPn = interpeduncular nuclei; LC = locus coeruleus; NA = nucleus ambiguus; OB = olfactory bulb; p.i. = post-injection; PirC = piriform cortex; Pn = pontine nuclei; PPT = pedunculopontine nucleus; RRF = retrorubral field; RsgC = retrosplenial granular cortex; SNr = substantia nigra pars reticulata; Thal = thalamus; VP = ventral pallidum; VTA = ventral tegmental area. See Supplementary Fig. 2 for data in control groups.