Fig. 7.

Validation of inflammatory features combined with IFN response of pregnant women by in vitro experiment. a–c Comparison of the MFI (mean fluorescence intensity) HLA-DR in intermediate, classical, and non-classical monocyte in stimulated compared to unstimulated blood samples by box plot and histogram. Freshly isolated blood samples withdrawn from pregnant (n = 6) and non-pregnant healthy controls (n = 6) were incubated with 1000 U/mL IFN-β, 1000 U/mL IFN-γ, or 25 ng/mL SARS-CoV-2 spike protein for 24 h. unsti unstimulated samples, sti stimulated samples. Barchart show median and interquartile range (IQR). Each dot represents an individual. Wilcoxon rank-sum test, adjusted for Bonferroni post hoc. *p < 0.05, **p < 0.01, ***p < 0.001