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. 2021 Jul 29;6:288. doi: 10.1038/s41392-021-00712-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Fusion inhibitory efficacy of EK1 peptides against SARS-CoV-2 on Caco2 and Calu-3 cells. a The fusogenic capacity of SARS-CoV-2 S protein on, lung cell line, Calu-3 (middle) and human intestinal cell line, Caco2 (bottom), 293T cell line (upper) was used as control. b, c Fusion inhibitory activity of EK1 and EK1C4 against the SARS-CoV-2 S-mediated fusion process on Calu-3 (b) and Caco2 (c) cells. d, e Inhibitory activity of EK1 and EK1C4 against pseudotyped SARS-CoV-2 infection on Calu-3 (d) and Caco2 (e) cells. f, g Antiviral effect of EK1 (5 μM) and EK1C4 (0.3 μM) against authentic SARS-CoV-2 infection on Calu-3 (f) and Caco2 (g) cells. Viral supernatant was collected 48 h of post-infection and quantified by qRT-PCR. ***P < 0.001