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. 2021 Jul 29;6:288. doi: 10.1038/s41392-021-00712-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Crystal structure of 6-HB formed by SARS-CoV-2-HR1 and EK1. a The structure of SARS-CoV-2-HR1 and EK1 is shown in cartoon representation with HR1 colored in green and EK1 in magenta. b HR1-trimer of SARS-CoV-2 is shown in electrostatic surface, and EK1 is shown in cartoon representation. c–e Interactions of SARS-CoV-2 HR1 motif against EK1 peptide and SARS-CoV-2 HR2 motif. Important binding residues are shown in sticks and labeled