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. Author manuscript; available in PMC: 2021 Jul 29.
Published in final edited form as: Nano Lett. 2021 Mar 9;21(6):2461–2469. doi: 10.1021/acs.nanolett.0c04759

Figure 2.

Figure 2.

DNA binding efficiency of pure PEI and PEI-g-ZIF NPs at various NPs:DNA mass ratios at 37 °C in (A) TE buffer and (B) TE buffer with 10% FBS. [DNA] = 0.5 μg/mL. The legends indicate NPs:DNA weight ratios. (C) DNA binding efficiency of different NPs at a weight ratio of NPs to DNA of 12.8/1 in the presence of heparin at different concentrations. [DNA] = 0.5 μg/mL. The legend indicates the heparin:DNA weight ratio. (D) Cytotoxicity of NPs at different concentrations to RAW 264.7 cells. The legend indicates NPs concentration (μg/mL). (E) CLSM images of colocalization of FITC-labeled PEI-g-ZIF NPs and Cy5-labeled CpG in lysosomes. Scale bar, 10 μm.