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. 2021 Jul 15;12:669787. doi: 10.3389/fimmu.2021.669787

Figure 2.

Figure 2

ST2 deficiency amplified the susceptibility to DSS-induced colitis. (A) DSS was orally administered to ST2-/- mice and BALB/c WT mice (n = 10-14 mice per group) for 6 days, followed by one day of normal drinking water. (B) Body weight changes relative to the initial weight and (C) disease activity index were monitored daily. (D) Histopathological score (n = 6) and (E) representative Hematoxylin and Eosin (H&E)-staining pictures of healthy control (ctrl) and inflamed colons (DSS) were evaluated on day 7. Scale bars represent 100 µm. (F) Secreted levels of IL-33, TNF-α and IL-6 were determined in the supernatants of colonic explants via Luminex technology. All data are presented as mean ± SEM. Statistical analyses were performed using two-way ANOVA, followed by Tukey’s multiple comparison test (B, C), unpaired Student’s t-test (D), or one-way ANOVA followed by Dunn’s or Dunnett’s multiple comparison test (F). *P < 0.05; ***P < 0.001.