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Immunological synapse (IS) of Natural Killer (NK) cell and target cell. (A) NK cells engage other cells to create an immunological synapse (IS); (B) First, filamentous actin (F-actin) is recruited to the IS; (C) NK lytic granules move along microtubules by dynein–dynactin motor proteins toward the microtubule-organizing center (MTOC); (D) the polarized lytic granules and MTOC dock at the IS, and degranulate (57).
