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. 2021 Jul 15;12:682094. doi: 10.3389/fimmu.2021.682094

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Copyright © 2021 Piatek, Tarkowski, Namiecinska, Riva, Wieczorek, Michlewska, Dulska, Domowicz, Kulińska-Michalska, Lewkowicz and Lewkowicz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in the DNA within H3K4me3-marked histone affect canonical NF-κB pathways. (A) The analyses of GO terms: alternative, canonical, and atypical NF-κB pathways. The bars represent mean values for HCs (n=3) and HIV-infected individuals (n=3) (B) The analysis of target genes in the GO term ‘Canonical NF-κB pathway’ indicated the lack of signals for TNF, ERC1, and IKBKG within H3K4me3 in HIV neutrophils (blue color). (C) The comparison of selected genes related to NF-κB shows a statistically significant smaller number of NGS readings (low density) within RelA, IKBKB, and TRAF6 coding genes related to the GO term ‘Canonical NF-κB pathway’.