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. 2021 Jul 15;12:682094. doi: 10.3389/fimmu.2021.682094

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Copyright © 2021 Piatek, Tarkowski, Namiecinska, Riva, Wieczorek, Michlewska, Dulska, Domowicz, Kulińska-Michalska, Lewkowicz and Lewkowicz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H3K4me3-associated genes affect apoptosis by deregulation of DNA fragmentation but not BCL2- or caspase-regulated execute phase of apoptosis. (A) Gene Ontology analysis of apoptosis and cell death. The bars represent mean values for HCs (n=3) and HIV-infected individuals (n=3). (B) Binding site overlap in the GO term ‘Apoptotic process’. A detailed list of all target genes is attached in the Supplementary Table 6 . (C) The comparison of peak density in the genes responsible for histone-1-induced DNA fragmentation revealed high density DNA within histone H1 in HIV neutrophils. (D) The comparison of peak in the representative genes responsible for execution phase of apoptosis as well as Bcl2 pathway revealed undetectable DNA within H3K4me3. ud- undetectable level of DNA.