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. 2021 Jul 15;11:714159. doi: 10.3389/fonc.2021.714159

Figure 4.

Figure 4

Lnc-TLCD2-1 is a sponge of miR-193a-5p in CRC. (A) The expression of miR-193a-5p was increased after CCL244 transfection with silnc-TLCD2-1. (B) The expression of miR-193a-5p was decreased after HCT116 transfection with veclnc-TLCD2-1. (C) Binding sites of lnc-TLCD2-1 and miR-193a-5p predicted by Starbase, the mutant sites we constructed were demonstrated. (D) MiR-193a-5p inhibitor obviously improved the dual luciferase activity of the lnc-TLCD2-1-wt reporter but not lnc-TLCD2-1-mut reporter in CCL244. (E) MiR-193a-5p mimic significantly reduced the dual luciferase activity of the lnc-TLCD2-1-wt reporter but not lnc-TLCD2-1-mut reporter in HCT116. (P<=0.05 means statistically significant, *p < 0.05, **p < 0.01).