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. 2021 Jul 15;11:714159. doi: 10.3389/fonc.2021.714159

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Copyright © 2021 Yu, Zhang, Zhou, Shen, Xing and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of lnc-TLCD2-1 and hsa-miR-193a-5p on YY1, and the effect of lnc-TLCD2-1 on CRC proliferation. (A) In CCL244, the expression of YY1 decreased after interference of lnc-TLCD2-1. (B) The expression of YY1 increased after overexpression of lnc-TLCD2-1 in HCT116. (C) YY1 was increased after inhibition of miR-193a-5p in CCL244. (D) YY1 was down-regulated after upregulation of miR-193a-5p in HCT116. (E) Western Blot detected the change of YY1 in protein level. (F) CRC proliferation was inhibited or promoted by interfering or upregulating the expression of lnc-TLCD2-1 in CCL244 and HCT116, respectively. (P<=0.05 means statistically significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.)