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. 2021 Jul 27;15:11782234211034937. doi: 10.1177/11782234211034937

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — TE inhibits cancer stem cells. (A) 410.4 or 66.1 cells plated in low attachment conditions and primary tumorspheres allowed to form in the presence of TE or PBS control. On day 10, tumorspheres were dissociated, and size expressed as cells per sphere. P values: *P < .01; **P < .0002; ***P < .00005; ****P < .000007. (B) 410.4 tumorspheres treated with vehicle or TE, tumorspheres harvested (day 8), dissociated and fraction of ALDH1 + cells determined. *P < .06. Fraction of ALDH1 + cells in secondary 66.1-derived tumorspheres. *P < .004; **P < .002. PBS indicates phosphate-buffered saline; TE, taro extract.