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. 2021 Jul 15;12:705284. doi: 10.3389/fgene.2021.705284

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Copyright © 2021 Hu, Sun, Zhou, Yi, Tang, Yao, Tian, Xie, Luo, Wang, Liao, Xu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Magnetic resonance images in three patients carrying novel NOTCH3 variants outside EGFr coding region. Fluid-attenuated inversion recovery images of the carrier of S2203Y (A–C), V1922L (D–F), and R1761H (G,H) showing multiple subcortical lacunar infarcts and characteristic diffuse leukoaraiosis with involvement of the external capsule. SWI images showed multiple microbleeds in basal ganglion and subcortical region of the carrier of R1761H (I).