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. 2021 Jul 15;11:697950. doi: 10.3389/fonc.2021.697950

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Copyright © 2021 Li, Chen, Chen, Hu, Yang, Zhuo, Chen, Yang, Zhou, Mao, Zhang, Xu, Ju, Shen, Wang, Dong, Xie, Wei, Jia, Zhou and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STAT5a knockdown sensitizes breast cancer cells to DOX in vivo. (A) Expression of STAT5a and ABCB1 in MCF7/DOX sh-NC cells and MCF7/DOX sh-STAT5a cells determined by Western blotting. (B) Survival rates of MCF7/DOX sh-NC and MCF7/DOX sh-STAT5a cells after treatment with DOX for 48 h. (C) Isolated subcutaneous tumors. (D) Tumor growth curves. (E) Weights of isolated tumors. (F) Nude mouse weight curves. (G) Expression of STAT5a, p-STAT5a and ABCB1 in MCF7/DOX sh-NC and MCF7/DOX sh-STAT5a tumors determined by IHC analysis. ns, p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.