Fig. 1.

devTOX^qP Assay Results for (-)-nicotine evaluated at 0.01–1,000 µg/mL. Nicotine was predicted to have the potential to cause developmental toxicity at 118 µg/mL or above via a non-cytotoxic mechanism. The horizontal red line represents the developmental toxicity threshold (0.85), the dashed horizontal grey line represents 1.0, and the red and blue filled circles indicate the dTP (118 µg/mL) and TP (618 µg/mL) concentrations, respectively. The x-axis is the concentration (µg/mL) of the test article. The y-axis is the vehicle-treatment normalized (fold change) values for the o/c ratio (purple line) and viability (black line). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)