Fig. 4.
devTOXqP Assay Results for A) ATRA, B) ATRA + 0.22% 1R6F bPBS. C) Combined o/c ratio graph for ATRA and ATRA + 0.22% 1R6F bPBS. The addition of 0.22% 1R6F bPBS to the positive compound ATRA did not cause a shift in the o/c ratio dose–response curve compared to ATRA alone. In all panels, the horizontal red line represents the developmental toxicity threshold (0.85), the dashed horizontal grey line represents 1.0, and the filled circles indicate the predicted dTP concentrations. The x-axis is the concentration of test articles (nM). The y-axis is the vehicle-treatment normalized (fold change) values for the o/c ratio and viability. ATRA + 0.22% 1R6F bPBS values are normalized to 0.22% 1R6F bPBS control data. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)