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a. CT cyclization routes. A and B represent two possible cyclization routes by the CT domain for the formation of fumiquinazoline F. b. Crystal structure of the holo T domain (gold) in conjunction with the CT domain (purple). The Ppant arm and the conserved histidine are drawn in pink. The salt bridge between E4019 (pink) of the β12 - β13 loop and R3652 (teal) of helix α2 is highlighted to show the closure of the solvent channel at the acceptor site.
