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. Author manuscript; available in PMC: 2021 Jul 29.
Published in final edited form as: Eur J Neurosci. 2018 Dec 10;49(1):79–93. doi: 10.1111/ejn.14283

FIGURE 1.

FIGURE 1

FSIs exhibit increased excitability in symptomatic Q175 mice. (a) Confocal images of biocytin-filled FSIs and sample responses of these cells to hyperpolarizing and depolarizing current injection in 12-month WT (left) and Q175 (right) mice. The fluorescence from cell somata was saturated to enhance the resolution of processes. Scale bar = 20 μm. (b) Rheobase measurements in WT and Q175 FSIs at 2 and 12 months. Depolarizing current pulses (5 ms) were injected into cells until firing was achieved. (c) Input–output curve for 12-month FSIs in response to a 1 sec duration current injection. Values are presented as mean ± SEM. Differences were considered statistically significant if p < 0.05 and are indicated in all figures with asterisks (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).