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. 2021 Jul 15;12:702048. doi: 10.3389/fimmu.2021.702048

Figure 5.

Figure 5

Clinical signs and inflammatory parameters after ZIKV infection of WT and IDO-/- mice infected by ZIKV. (A) Experimental schematic representation of experimental strategy. C57BL/6 and IDO-1-/- were inoculated (intracranial) with 1x106 PFU/20μL of ZIKV. (B) The body weight was evaluated daily and (C) the intraocular pressure was analyzed on days 0, 3 and 5. At day 5 of infection, (D) the brain was harvested and myeloperoxidase absorbance analysis and (E–H) chemokine/cytokine production was assessed. All results are expressed as mean and error bar indicate the standard error (SEM) and are representative of at least two independent experiments. Statistically significant differences were assessed by Two-way ANOVA plus Tukey’s comparisons test (B, C) and One-way ANOVA plus Tukey’s comparisons test (D-H). (###) for P < 0,001 and (####) for P < 0,0001 compared to the MOCK group.