Figure 1.

Low intake of dietary fiber accelerates disease in lupus-prone NZB/WF1 mice. (A) Overall survival (OS) determined in lupus-prone NZB/WF1 mice fed a high (HF; n = 19), normal (NF; n = 18) or low fiber (LF; n = 18) diet. The Kaplan–Meier method was used for estimating OS in differently treated groups. (B–D) Determination of (B) total anti-dsDNA-IgG, -IgG1 and -IgG2a serum titers, (D) lymphoproliferation by spleen weight, (C, E) signs of beginning nephritis by kidney-infiltrating CD45⁺ leukocytes and proteinuria levels, in 28 w old animals fed a HF (n = 14–17 mice), NF (n = 16 mice) or LF (n = 15–19 mice) diet. Results are expressed as scatter blots with mean ± SEM; each data point represents an individual mouse; p < 0.05 was considered significant, p > 0.2 is indicated as ns, not significant.