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The mechanism of LRRK2 leading to microglia activation. Abnormal LRRK2 activity could regulate microglia cells’ activation through hyperphosphorylation of PKA, p53, MAPK family proteins, and Drp1. Thus, LRRK2 drives microglia toward a reactive phenotype with enhanced cell activity and inflammation in response to inflammatory stimuli, including LPS, environmental insults, and neuronal susceptibility.
