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. 2021 Jul 19;19(7):e3001341. doi: 10.1371/journal.pbio.3001341

Fig 4. Spatial expression patterns reflect distance in semantic space, but not physical distance in the brain.

Fig 4

Cross-dataset AUROCs (x-axis) of classifying all leaf brain areas from all other leaf brain areas for (A) ABA using LASSO (lambda = 0.1) trained in ST and (B) ST using LASSO (lambda = 0.1) trained in ABA as a function of path length (x-axis) in the ARA naming hierarchy between the 2 brain areas being classified. The same AUROCs (y-axis) from (A) and (B) shown in (C) and (D), respectively, as a function of minimum Euclidean distance between the 2 brain areas in the ARA (x-axis). Euclidean distance on the x-axis is binned into deciles for visualization. All 4 plots show mean AUROCs (points) with standard deviation (vertical bars). ABA, Allen Brain Atlas; ARA, Allen Reference Atlas; AUROC, area under the receiver operating curve; LASSO, least absolute shrinkage and selection operator; ST, spatial transcriptomics.