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. 2021 Jul 15;9:675424. doi: 10.3389/fcell.2021.675424

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Copyright © 2021 Liu, Liu, Sun, Gao, Ai, Chen, Sun, Zhou, Liu, Xiong and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioinformatic search for genes mutated mutually exclusively with genes known to be involved in DNA de/methylation. (A) Illustration of the rationale for identifying genes that may function in the same pathway with epigenetic genes. (B) Mutation rate of epigenetic genes across 10 cancer types. Data was obtained from cBioportal. (C) Schematic diagram of methodology for identifying genes that show mutual exclusivity with mutations targeting IDH, TET, and DNMT family genes. (D) Selected mutually exclusive mutation pairs in AML and LGG. (E) Heatmap showing the mutually exclusive mutational pattern of gene pairs. The number of patients for each analysis is indicated on the right.