Table 2.

Covariation in the Expression of Bone Marker Genes.

Young WT Bone
	runx2b	col10a1	AP	TRAP	osx	ptch1	col2a1a	csf1ra	gli1	ptch2
runx2b		0.413	0.637	0.757	0.022	0.480	0.080	0.869	0.830	0.343
col10a1	0.200		0.119	0.630	0.114	0.003	0.654	0.558	0.040	0.124
AP	−0.116	0.370		0.004	0.098	0.509	0.200	0.814	0.115	0.040
TRAP	0.076	−0.118	−0.622		0.356	0.649	0.922	0.426	0.025	0.007
osx	0.523	0.375	−0.391	−0.224		0.002	0.293	0.872	0.804	0.123
ptch1	−0.172	−0.637	0.161	−0.112	0.659		0.866	0.778	0.005	0.916
col2a1a	0.411	−0.110	0.308	0.024	−0.254	0.041		0.009	0.205	0.596
csf1ra	−0.041	0.143	0.058	0.194	0.040	0.069	0.585		0.310	0.395
gli1	0.053	0.475	0.374	0.511	−0.061	0.612	−0.305	0.246		0.019
ptch2	0.230	−0.365	−0.476	−0.601	−0.366	−0.026	−0.130	0.207	0.531
Young Mutant Bone
	runx2b	col10a1	AP	TRAP	osx	ptch1	col2a1a	csf1ra	gli1	ptch2
runx2b		0.026	0.176	0.000	0.420	0.169	0.425	0.205	0.754	0.244
col10a1	−0.474		0.177	0.664	0.030	0.448	0.052	0.785	0.734	0.132
AP	0.299	0.299		0.145	0.482	0.913	0.123	0.304	0.161	0.597
TRAP	0.746	0.098	−0.322		0.860	0.307	0.822	0.158	0.910	0.727
osx	0.181	0.462	−0.158	−0.040		0.002	0.083	0.928	0.000	0.845
ptch1	0.304	0.171	−0.025	−0.228	0.622		0.251	0.060	0.000	0.736
col2a1a	0.179	0.419	0.339	−0.051	−0.378	−0.256		0.015	0.553	0.521
csf1ra	−0.281	0.062	−0.229	0.312	−0.020	0.407	0.512		0.452	0.537
gli1	−0.071	−0.077	−0.309	−0.026	−0.702	0.768	0.134	−0.169		0.657
ptch2	−0.259	−0.332	0.119	0.079	−0.044	0.076	−0.144	0.139	0.100
Old WT Bone
	runx2b	col10a1	AP	TRAP	osx	ptch1	col2a1a	csf1ra	gli1	ptch2
runx2b		0.028	0.051	0.008	0.001	0.000	0.013	0.078	0.151	0.063
col10a1	−0.549		0.007	0.001	0.000	0.005	0.000	0.735	0.000	0.230
AP	−0.496	−0.641		0.175	0.005	0.229	0.011	0.182	0.003	0.630
TRAP	−0.633	−0.735	−0.357		0.000	0.000	0.001	0.195	0.051	0.051
osx	0.752	0.832	0.664	0.904		0.002	0.000	0.590	0.004	0.087
ptch1	0.771	0.663	0.319	0.781	−0.708		0.000	0.083	0.049	0.037
col2a1a	0.606	0.867	0.618	0.768	−0.772	−0.775		0.674	0.005	0.221
csf1ra	−0.453	0.092	0.351	−0.342	0.146	0.447	0.114		0.131	0.679
gli1	−0.376	−0.873	−0.701	−0.496	0.681	0.499	0.664	0.394		0.433
ptch2	−0.475	−0.318	−0.131	−0.495	0.441	0.525	0.324	−0.112	−0.211
Old Mutant Bone
	runx2b	col10a1	AP	TRAP	osx	ptch1	col2a1a	csf1ra	gli1	ptch2
runx2b		0.025	0.011	0.664	0.000	0.747	0.000	0.843	0.211	0.124
col10a1	−0.699		0.000	0.648	0.025	0.400	0.005	0.636	0.529	0.006
AP	0.761	0.954		0.498	0.029	0.740	0.004	0.586	0.298	0.020
TRAP	−0.157	−0.165	0.243		0.408	0.225	0.850	0.807	0.117	0.668
osx	0.926	0.698	−0.685	0.295		0.715	0.000	0.942	0.207	0.117
ptch1	0.117	0.300	−0.121	−0.422	−0.133		0.470	0.713	0.072	0.379
col2a1a	0.967	0.807	−0.822	0.069	−0.915	−0.259		0.674	0.343	0.022
csf1ra	−0.072	−0.172	0.197	0.089	0.027	−0.134	0.152		0.127	0.252
gli1	0.433	0.226	−0.366	0.528	−0.437	0.590	−0.336	0.516		0.824
ptch2	0.519	0.795	−0.715	−0.155	−0.528	−0.312	−0.709	0.400	−0.081

Note.—Partial correlation coefficients (below diagonal) and P values (above diagonal) are shown for both genotypes at young (3–5 months) and old (10–15 months) stages. Values are italicized if significant at the ∼0.05-level.