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. 2021 Aug 2;131(15):e148542. doi: 10.1172/JCI148542

Figure 5. NKG2A/C+CD8+ T cells exhibit transcriptional and functional features of TVMs.

Figure 5

(A) Abundance of transcripts commonly expressed by TVMs in sorted cell populations from 6 RhCMV+ and 6 RhCMV– rhesus macaques. (B) Left: Representative histogram showing expression of EOMES among gated NKG2A/C+CD8+ T cells, NKG2A/C–CD8+ T cells or NK cells. Right: Percentage of EOMES+ in the 3 gated populations from 5 different macaques. Dynamics (C) and Ki-67 expression (D) of NKG2A/C+CD8+, NKG2A/C–CD8+ T cells and NK cells following treatment of 3 RhCMV+ rhesus macaques with recombinant IL-15 (10 μg/kg) and IL-15Rα (40 μg/kg). Box plots show the median value, 25th and 75th quartiles, and the range of values. Wilcoxon signed-rank tests were used to compare values. *Adjusted P < 0.05, **Adjusted P < 0.001.