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. 2021 Aug 2;131(15):e146323. doi: 10.1172/JCI146323

Figure 6. Both presynaptic and postsynaptic mechanisms are involved in the synaptic potentiation induced by LAMB1 knockdown in the ACC.

Figure 6

Representative paired-pulse traces (A) and quantitative summary (B) of PPF or PPD showing that LAMB1 knockdown led to a reduced PPR (n = 20). **P < 0.01, by 2-tailed, unpaired t test. (C–E) Representative traces (C) and quantification of mEPSC frequency (D) and amplitude (E) showing that LAMB1 knockdown significantly increased mEPSC frequency and amplitude (n = 8–11). **P < 0.01, by 2-tailed, unpaired separate variance estimation t test (D) and 2-tailed, unpaired t test (E). (F and G) Inward currents induced by bath-applied AMPA (50 μM) (F) or NMDA (50 μM) (G) in mice of both genotypes (n = 6–7). *P < 0.05, by 2-tailed, unpaired t test. Data are presented as the mean ± SEM. See Supplemental Table 2 for detailed statistical information.