Table 1. Patient and tumor data for all patients. Patients were divided by treatment intent and by HPV status of the tumor.

	All	Curative	Palliative	p Value	HPV+	HPV−	p Value
Subjects, n	260	216	44		81	18
Age (years)
Mean (SD)	65.3 (13)	62.5 (11)	79.0 (12)	0.017	60.5 (10)	67.9 (13)	0.017
Median (range)	64 (37–95)	62 (37–92)	83 (54–95)		61 (37–87)	70 (47–91)
Gender, n (%)
Male	191 (73)	165 (76)	26 (59)	0.024	61 (75)	12 (67)	0.56
Female	69 (27)	51 (24)	18 (41)		20 (25)	6 (33)
Smoking habits
Never smoker	19 (34)	17 (33)	2 (40)	0.79	9 (35)	1 (50)	0.51
Former smoker a	23 (41)	22 (43)	1 (20)		12 (46)	1 (50)
Smoker	14 (25)	12 (24)	2 (40)		5 (19)	0
Performance status b
0	188 (80)	179 (89)	9 (26)	< 0.001	69 (95)	14 (82)	0.32
1	23 (10)	19 (9)	4 (12)		3 (4)	2 (12)
2	8 (3)	3 (1)	5 (15)		0	1 (6)
3–4	16 (7)	0	16 (47)		1 (1)	0
Tumor histology
SCC	234 (90)	202 (94)	32 (73)	< 0.001	80 (99)	15 (83)	0.018
Carcinoma N/S	26 (10)	14 (6)	12 (27)		1 (1)	3 (17)
HPV status
Positive	81 (82)	80 (84)	1 (25)	0.018	.	.	.
Negative	18 (18)	15 (16)	3 (75)		.	.
N stage
N1	62 (24)	53 (25)	9 (22)	0.006	24 (30)	3 (17)	0.14
N2	160 (63)	139 (65)	21 (51)		51 (63)	12 (67)
N3	34 (13)	23 (11)	11 (27)		6 (7)	3 (17)
M stage
M0	244 (95)	216 (100)	28 (68)	< 0.001	80 (99)	16 (89)	0.084
M1	13 (5)	0	13 (32)		1 (1)	2 (11)

Abbreviation: HPV, human papillomavirus; SCC, squamous cell carcinoma; SD, standard deviation.

^aFormer smoker quit smoking at least 1 year ago.

^bWHO Performance status.