Figure S8. RNA-seq analysis indicates Steroid hormone biosynthesis inhibition in M3^−/− crypts.

(A) Steroid hormone biosynthesis (mmu00140) maps derived from Database for Annotation, Visualization, and Integrated Discovery analysis. Green boxes and arrows indicate the genes and interactions in the pathway. +p and −p denote phosphorylation and dephosphorylation, respectively. The genes with red stars are those that were down-regulated in M3^−/− crypts. (B) Differential expression patterns of CYP2e1, CYP3a11, CYP3a13, CYP2c40, CYP3a25, CYP2c55, and CYP2d26 in M3^−/− crypts. Data information: The results of RNA-seq are based on three independent experiments and are presented as mean values ± SD. The statistical significance was calculated with t test (*P < 0.05 and **P < 0.005).

Source data are available online for this figure.