Figure S2. Induction of eosinophils and macrophages in cerulein-with-AOM–treated murine model of chronic pancreatitis.

A number of CCR3⁺ SiglecF⁺ eosinophils in saline, cerulein-treated mice compared with the highly induced eosinophils detected in splenocytes of cerulein-with-AOM–treated mice (Ai–v). (B, Ci–iv, D) CD11b⁺ CD86⁺ M1 macrophages and CD11b⁺ CD206⁺ M2 macrophages were induced in cerulein-with-AOM–treated mice compared to cerulein-treated mice, and a few macrophages observed in saline- and AOM-treated mice (B, Ci–iv, D). (Ei–v) Number of CD11b⁺ macrophages in cerulein-treated mice compared with the highly induced macrophages detected in splenocytes of cerulein-with-AOM–treated mice (Ei–v). Data are presented as means ± SD, *P < 0.05, ##P < 0.001, *** or ###P < 0.0001. *Represents cerulein versus saline and AOM, # cerulein with AOM versus saline and AOM. n = 4 mice/group. All photomicrographs shown are the original magnification 400× and 600× (scale bar 20 and 10 µm).