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. 2021 Jun 2;321(1):G87–G97. doi: 10.1152/ajpgi.00090.2021

Figure 1.

Figure 1.

A: time-course effect of BDNF on the basal IAS tone showing significant (t test; *P < 0.05; n = 10 observations from 6 animals) increase in young and aging rats. Addition of BDNF or K252a has been denoted by the arrows in the respective experiments. The respective controls represent steady basal tone in the young and aging groups, without the addition of any agent. B: typical tracings showing the effects of BDNF and K252a on the basal IAS tone in both age groups of animal. C: whisker plot showing that BDNF produces a significant (one-way ANOVA; *P < 0.05; n = 10 observations from 6 animals) and sustained increase in the established basal IAS tone in young and aging rats, determined at the end of 1 h from the beginning of the treatment. These data show that BDNF rescues the aging-associated decrease in the basal IAS tone to the levels not significantly different from that of the young group (P > 0.05). BDNF, brain-derived neurotropic factor; IAS, internal anal sphincter; K252a, TrkB inhibitor.