Figure 5.

BDNF significantly (one-way ANOVA; *P < 0.05) rescues (by attenuating) the NANC nerve stimulation-induced increased release of NO in the aging groups to the levels not significantly different from the control young group. Conversely, however, in the young group, BDNF augments the NANC relaxation in parallel with the increased levels of NO release. All BDNF-induced changes in the NANC relaxation and NO release were attenuated by K252a (B + K) (one-way ANOVA; *P < 0.05; n = 10 observations from 6 animals), whereas K252a by itself has no significant effect on these parameters (P > 0.05). BDNF, brain-derived neurotropic factor; K252a, TrkB inhibitor; NANC, nonadrenergic noncholinergic; NO, nitric oxide.