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. 2021 Jun 2;321(1):G87–G97. doi: 10.1152/ajpgi.00090.2021

Figure 6.

Figure 6.

Data show that BDNF significantly (one-way ANOVA; *P < 0.05; n = 10 observations from 6 animals) rescues aging-associated increase in the IAS relaxation in response to SNP (100 nM) to the levels not significantly (P > 0.05) different from the control young group (P > 0.05). BDNF-induced changes in SNP responses were significantly (*P < 0.05; n = 10 observations from 6 animals) attenuated by K252a (B + K) (*P < 0.05), which by itself has no significant effect (P > 0.05). BDNF, brain-derived neurotropic factor; IAS, internal anal sphincter; K252a, TrkB inhibitor; SNP, sodium nitroprusside.