Figure 8.

Data show that BDNF significantly rescues (t test; *P > 0.05; n = 50 cells from 6 animals) the aging-associated reduced SMC contractility in response to U46619 (A) and ANG II (B), to the levels not significantly different from the control values in young group (P > 0.05). This effect of BDNF is attenuated by K252a, which by itself has no significant effect (P > 0.05). C: conversely, BDNF failed to modify the effects of KCl. ANG II, angiotensin II; BDNF, brain-derived neurotropic factor; KCl, potassium chloride; K252a, TrkB inhibitor; SMC, smooth muscle cell; U46619, thromboxane A₂ analog.