Figure 5.
Deletion of neural precursor cell expressed developmentally downregulated 4-2 (Nedd4-2) abolishes the effect of K+ diets on hydrochlorothiazide (HCTZ)-induced natriuresis. Shown is HCTZ-induced net renal Na+ excretion in control and kidney tubule-specific Nedd4-2 knockout (Ks-Nedd4-2 KO) mice on low K+ (LK), normal K+ (NK), and high K+ (HK) diets for 7 days. Individual data points are indicated by black circles. Significance was determined by two-way ANOVA. BW, body weight; Neddlflox/flox, floxed neural precursor cell expressed developmentally downregulated 4-like mice.