Figure 8.
Epithelial Na+ channel (ENaC) expression is stimulated in kidney tubule-specific neural precursor cell expressed developmentally downregulated 4-2 knockout (Ks-Nedd4-2 KO) mice on high K+ (HK). A: expression of full-length (F-)ENaCα, cleaved (C-)ENaCα, ENaCβ, and ENaCγ in three control (male) and three Ks-Nedd4-2 KO (male) mice on normal K+ (NK) or HK for 7 days. The arrow indicates cleaved formed ENaCγ. B: bar graph showing the normalized band density of ENaCα (full-length and cleaved forms), ENaCβ, F-ENaCγ, and C-ENaCγ. *Significant difference (P < 0.05); #significant difference compared with the other groups. Significance was determined by two-way ANOVA. Neddlflox/flox, floxed neural precursor cell expressed developmentally downregulated 4-like mice.