Figure 4.

Thick ascending limb-selective G protein-coupled receptor (GPCRs). GPCR expression data from microdissected renal tubules were filtered based on an individual genes’ maximum expression [in transcripts per kilobase million (TPM)] in either the cortical thick ascending limb (CTAL) or medullary thick ascending limb (MTAL) compared with its expression in any other tubule segment. MTAL/CTAL expression that was 1.5-fold greater than any other tubule segment was considered selective. Entries are sorted starting with the greatest TPM ratio. Refer to Table 4 for additional information about each GPCR. ATL, thin ascending limb of the loop of Henle; CCD, cortical collecting duct; CNT, connecting tubule; DCT, distal convoluted tubule; DTL1, short descending limb of the loop of Henle; DTL2, long descending limb of the loop of Henle in the outer medulla; DTL3, long descending limb of the loop of Henle in the inner medulla; Glom, glomerulus; IMCD, inner medullary collecting duct; PTS1, initial segment of the proximal convoluted tubule; PTS2, proximal straight tubule in cortical medullary rays; PTS3, last segment of the proximal straight tubule in the outer stripe of outer medulla; OMCD, outer medullary collecting duct.