Table 3.
Proximal tubule-selective G protein-coupled receptors
| Gene Symbol | Annotation | Ligand | G Protein | Renal Physiological Process | Key Reference(s) |
|---|---|---|---|---|---|
| Lpar3 | Lysophosphatidic acid receptor 3 | Lysophosphatidic acid | Gαi/Gαq | Segment function not known. Blockade reduces ischemia-reperfusion injury | (24) |
| Cckar | Cholecystokinin A receptor | Cholecystokinin | Gαq/Gαs | Segment function not known. Proposed role in the natriuretic response | (25) |
| Sucnr1 | Succinate receptor 1 | Succinic Acid | Gαi/Gαq | Succinate binding induces renin release | (26, 27) |
| Agtr1a | angiotensin II receptor, type 1a | Angiotensin II | Gαi/Gαo/ Gαq | Na+/K+-ATPase activity, HCO3− HCO3− reabsorption, renin-angiotensin system activation | (28–31) |
| Adra2b | Adrenergic receptor, α2b | Epinephrine/norepinephrine | Gαi/Gαo | MAPK activation, Na+-K+-ATPase activity | (32–34) |
| Adgrg4 | Adhesion G protein-coupled receptor G4 | Orphan | Kidney function not known | ||
| Adra1a | Adrenergic receptor, α1a | Epinephrine/norepinephrine | Gαq/Gα11 | Na+ absorption | (35, 36) |
| Lpar6 | Lysophosphatidic acid receptor 6 | Lysophosphatidic acid | Gαs/Gαi/ Gα12 | Segment function not known | |
| Pth1r | Parathyroid hormone 1 receptor | Parathyroid hormone | Gαs | Inhibits phosphate/bicarbonate absorption | (5, 37–39) |
Shown are known ligands, coupled G protein α-subunits, and segment-specific physiological roles for G protein-coupled receptors selectively expressed in the proximal tubule.