Table 5.
Distal convoluted tubule- and connecting tubule-selective G protein-coupled receptors
| Gene Symbol | Annotation | Ligand | G Protein | Cell Type | Renal Physiological Process | Key References |
|---|---|---|---|---|---|---|
| Distal convoluted tubule | ||||||
| Adora2b | Adenosine A2b receptor | Adenosine | Gαs | Induce H secretion via V-ATPase | (78–80) | |
| Ptgfr | Prostaglandin F receptor | Prostaglandin F | Gαq/Gα11 | Principal cells | Modulates K channels | (81–83) |
| Connecting tubule | ||||||
| Sctr | Secretin receptor | Secretin | Gαs | β-Intercalated cells > α-intercalated cells | Segment function not known | (84, 85) |
| Fzd7 | Frizzled class receptor 7 | Wnt | Gαs/Gαi | Also signals through Wnt, segment function not known | ||
| Oxgr1 | oxoglutarate receptor 1 | α-ketoglutarate | Gαq/Gα11 | α-Intercalated cells > β-intercalated cells > principal cells | Segment function not known | (26, 86) |
Known ligands, coupled G protein α-subunits, cell type-specific expression, and segment-specific physiological roles for G protein-coupled receptors selectively expressed in the distal convoluted tubule and connecting tubule are shown.