Table 6.

Collecting duct-selective G protein-coupled receptors

Gene Symbol	Annotation	Ligand	G Protein	Cell Type	Renal Physiological Process	Key Reference(s)
Adgrf1	Adhesion G protein-coupled receptor F1	Orphan			Kidney function not known
Ptger1	Prostaglandin E receptor 1	Prostaglandin E2	Gαq/Gα11	Principal cells	Inhibits Na+ absorption	(101, 102)
P2ry14	Purinergic receptor P2Y, G protein coupled, 14	UDP-glucose	Gαi	α-Intercalated cells	Inflammatory response	(103, 104)
Gprc5b	G protein-coupled receptor, family C, group 5, member B	Orphan		Principal cells	Kidney function not known
Adgrf5	Adhesion G protein-coupled receptor F5	Tethered agonist	Gαq/Gα11	α-Intercalated cells	V-ATPase trafficking	(105)
Npy6r	Neuropeptide Y receptor Y6	Neuropeptide Y/peptide YY/pancreatic peptide		Principal cells	Segment function not known, pseudogene in humans	(106)
Fzd1	Frizzled class receptor 1	Wnt	Gαi/Gαq	Principal cells	Also signals through Wnt
Npy1r	Neuropeptide Y receptor Y1	Neuropeptide Y/peptide YY	Gαi/Gαo		Kidney function not known	(106)
Avpr2	Arginine vasopressin receptor 2	Arginine vasopressin	Gαs	Principal cells	Water reabsorption	(7, 107, 108)
Celsr2	Cadherin, EGF LAG seven-pass G-type receptor 2	Orphan		Principal cells > β-intercalated cells > α-intercalated cells
Lpar1	Lysophosphatidic acid receptor 1	Lysophosphatidic acid	Gαi/Gαq/Gα12	Principal cells	Segment function not known
Gper1	G protein-coupled estrogen receptor 1	17β-Estradiol	Gαi/Gαo	Principal cells	Ca2+-H+-ATPase	(109)
S1pr3	Sphingosine-1-phosphate receptor 3	Sphingosine-1 phosphate	Gαi/Gαq	β-Intercalated cells	Kidney function not known	(110)

Known ligands, coupled G protein α-subunits, cell type-specific expression, and segment-specific physiological roles for G protein-coupled receptors selectively expressed in the collecting duct are shown.