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. 2021 Jun 11;321(1):H185–H196. doi: 10.1152/ajpheart.00118.2021

Figure 1.

Figure 1.

Apigenin selectively enhances endothelial function in old mice by increasing nitric oxide (NO) bioavailability. A: carotid artery dose responses to the endothelium-dependent dilator acetylcholine (ACh) in young and old controls (YC and OC) and young and old apigenin-supplemented (YA and OA) mice (n = 7–10/group) with and without coadministration of the NO synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME). B: NO-mediated dilation [peak dilation of ACh (−) peak dilation of ACh + l-NAME] (n = 7–10/group). C: dose responses to the endothelium-independent dilator sodium nitroprusside (SNP) (n = 7–10/group). Values are means ± SE; n, number of mice/group. *P < 0.05 vs. all other groups (under ACh-only conditions in A).