Table 2.
Hub gene identification within significant LVW/BW associated modules
| Gene Sig Fibrosis | P Value | Module Membership | P Value | Relevant Biological Function | |
|---|---|---|---|---|---|
| Midnightblue | |||||
| Symbol | |||||
| Mid2 | 0.76 | 0.0175 | 0.9879 | 6.29E-07 | E3 ubiquitin ligase ( 35 ); Identified in human urinary exosomes ( 36 ) |
| Slc36a4 | 0.79 | 0.0112 | 0.9846 | 1.48E-06 | Amino acid transporter; Regulates Golgi-associated mTORC1 ( 37 ) |
| Extl3 | 0.78 | 0.0126 | 0.9824 | 2.32E-06 | Mediates TN-α-induced NF-κB activity ( 38 ); identified in milk fat exosomes ( 39 ) |
| Tmem87b | 0.79 | 0.0109 | 0.9816 | 2.75E-06 | Endosome-to-Golgi retrograde transport ( 40 ); mutation linked with restrictive cardiomyopathy ( 41 ); identified in human tumor-derived exosomes ( 42 ) |
| Rab3gap2 | 0.85 | 0.0035 | 0.9778 | 5.25E-06 | Family of proteins that regulates exocytosis of neurotransmitters and hormones; identified in human neuroblastoma-derived exosomes ( 43 ) |
| Man2b2 | 0.88 | 0.0020 | 0.9776 | 5.43E-06 | lysosomal degradation of glycoproteins; identified in human urine exosomes ( 44 ) |
| Aph1b | 0.82 | 0.0062 | 0.9773 | 5.67E-06 | Male-specific association with atherosclerosis (45,46) |
| Gnas | 0.75 | 0.0203 | 0.9763 | 6.63E-06 | GPCR signaling via guanine nucleotide binding; associated with diastolic function in patients with heart failure (47); sex-dependent association with obesity (48); identified in exosomes from multiple sources (20, 49–55) |
| Tmem241 | 0.70 | 0.0340 | 0.9732 | 1.01E-05 | Contributes to increased triglyceride levels (56) |
| Dse | 0.83 | 0.0054 | 0.9727 | 1.08E-05 | Golgi associated protein linked with ECM-related Ehlers-Danlose syndrome ( 57 ) |
| Skyblue | |||||
| Rnf10 | 0.79 | 0.0108 | 0.9875 | 7.14E-07 | Diabetic vascular remodeling via vascular smooth muscle cell proliferation (58); Aging related inflammation (59) |
| Rnft2 | 0.70 | 0.0353 | 0.9829 | 2.13E-06 | Negative regulator of IL-3-mediated inflammation (60) |
| Mmp15 | 0.77 | 0.0159 | 0.9802 | 3.55E-06 | Adipose expression associated with obesity-mediated insulin resistance ( 61 ); Found in human tumor-derived exosomes ( 42 ) |
| Bicd2 | 0.76 | 0.0177 | 0.9764 | 6.48E-06 | Required for exosome transport in motor neurons ( 62 ) |
| Dnaaf9 | 0.72 | 0.0287 | 0.9761 | 6.74E-06 | Unknown |
| Ust | 0.84 | 0.0049 | 0.9760 | 6.90E-06 | Tumor cell adhesion and migration (63,64); regulates Wnt signaling (65) |
| Myo19 | 0.69 | 0.0413 | 0.9747 | 8.24E-06 | Intracellular transport of mitochondria (66,67) |
| Ckap4 | 0.74 | 0.0222 | 0.9730 | 1.04E-05 | Found in multiple human tumor-derived exosomes (42, 68–70); Identified in adipocyte-derived exosomes in rats (71) |
| Rhoc | 0.70 | 0.0352 | 0.9724 | 1.12E-05 | Found in multiple human tumor-derived exosomes (42,43, 68, 70, 72); Regulates exosome secretion (73) |
| Cyp4f16 | 0.77 | 0.0157 | 0.9707 | 1.38E-05 | Metabolism of proinflammatory compounds (74) |
ECM, extracellular matrix; GPCR, G-protein-coupled receptors.